Prothena’s success is driven by our people. We are dedicated to attracting individuals who share our vision to improve human health by putting patients first.

But it’s not just about what we do at Prothena, it’s how we do it. That’s why we hire creative and courageous individuals who support one another and are not afraid to try new ideas. Our culture reflects our values which are brought to life every day by the following characteristics:

SELFLESS - Patients come first and we’re in this together. Our environment is collaborative and we measure success through our collective accomplishments.

COURAGEOUS - Transformational innovation leads to novel treatments. “Tried-and-true” won’t produce breakthroughs for patients – a pioneering spirit, willingness to accept certain risks and to try new approaches. Each Prothenian and functional team is expected to bring their heart, experience and trust on our journey.

IMAGINATIVE - We value and encourage a creative approach across all aspects of our work. We challenge ourselves and each other to think beyond what is known and approach our work through a lens of continuous improvement.

JOYFUL - Humor and heart allow us to tackle the seriousness of our work. Excellence and fun are not at odds – we love what we do and enjoy the journey.

Position Overview:

Reporting to the SVP Head of Clinical Development, you are responsible for implementing the development strategy, through design, execution, monitoring and interpretation of clinical study data in neurodegeneration. In this role you will interact with multiple functions and management within Prothena, and with key external stakeholders.

Responsibilities:

• Input into the development program strategy across Prothena’s neurodegeneration assets.
• Overall responsibility for all aspects of end-to-end clinical trial including design, execution, interpretation and reporting of efficacy and safety across one or more clinical trials
• Partner seamlessly with program management, biometrics, regulatory, clinical operations, development sciences, drug safety, and other functions to ensure successful development program delivery
• Develop key design elements across clinical trial protocols
• Responsible for high impact global decisions: monitoring and interpreting data from ongoing internal and external studies, assessing the medical and scientific implications and making recommendations that impact regional and global development such as “go/no go” decisions, modification of development plans or study designs that may have a significant impact on timelines or product labeling

Requirements:

Education and Experience:

• D / Ph.D., M.D., (Neurology) or Ph.D. required, with clinical or research experience in neuroscience.
• Ability to think critically and demonstrate troubleshooting and problem-solving skills.
• Demonstrated leadership and team building skills as well as the ability to perform effectively in a multi-disciplinary environment.
• Ability to lead directly and by influence, including strong interpersonal, problem solving, conflict resolution and analytical skills in a matrix environment.
• Excellent communication skills (oral and written) and organizational skills.
• Knowledge of Good Clinical Practices (GCP), FDA and EMEA/CHMP regulations and guidelines, and applicable international regulatory requirements Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication
• Demonstrated ability as a medical expert in a complex matrix environment
• Provides leadership for the conduct of clinical studies.

Competencies and Attributes:

• Demonstrated leadership to drive results that are needed to achieve company objectives in accord with Prothena’s culture and values – courageous, imaginative, selfless, and joyful

Compensation Overview:

The anticipated annual salary range for this role at Director job level is $220,000 - $285,000. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. We may ultimately pay more or less than the posted range, and the range may be modified in the future. The final salary offered to a successful candidate will be dependent on several factors that may include – but are not limited to – the final job level offered, the type and length of experience within the job and industry, relevant education, qualifications, skills, certifications, performance, and business or organizational needs.

The hired applicant will be eligible to receive an annual bonus and an equity grant in the form of stock options.

Health & Wellness Benefits, 401(k) and PTO Overview:

• All Prothena employees (and their families) are covered by medical, dental, and vision insurance, with Prothena paying ~90% of plan premiums.
• Prothena pays the full premium for basic life and disability insurance for all employees.
• Prothena employees are also eligible to enroll in our Company’s 401(k) plan and are always 100% vested in their account balances. The 401(k) plan provides for a quarterly, non-discretionary, 3% company-paid contribution on eligible earnings, as well as an additional, annual discretionary Company match of up to 2% of eligible earnings.
• New Prothena employees are also eligible for 17 days of paid vacation accrued over the course of the first year of employment, paid sick time in accordance with state law, and company-paid holidays – which includes a Company-wide shutdown at the winter holidays.

More information about Prothena can be found at the Company’s website: www.prothena.com.